Project Title: Field evaluation of RNAi-based attractive targeted sugar baits for control of Anopheles mosquitoes
Project Description: The development of transformative, environmentally friendly, cost-effective new mosquito control is critical for preventing the spread of malaria parasites in Sub Saharan Africa and other parts of the world. Attractive toxic sugar baits (ATSBs), a new paradigm for vector mosquito control, exploit the sugar feeding behavior of female and mosquitoes that are ruled to feed on sugar source containing an insecticide. Mosquito-specific resistance, significantly enhance ATBS Technology, and reduce outdoor residual transmission. Recent high- throughput... The development of transformative, environmentally friendly, cost-effective new mosquito control is critical for preventing the spread of malaria parasites in Sub Saharan Africa and other parts of the world. Attractive toxic sugar baits (ATSBs), a new paradigm for vector mosquito control, exploit the sugar feeding behavior of female and mosquitoes that are ruled to feed on sugar source containing an insecticide. Mosquito-specific resistance, significantly enhance ATBS Technology, and reduce outdoor residual transmission. Recent high- throughput screen in the scheel laboratory identified hundreds of IRPs, a subset of which have 25 bp target sites that are conserved in many species of diseases vector mosquitoes, but that are not found in human or other non-target organisms, and which kill both larvae and adults. The long-term goal of the proposed research program is to develop an ATSBs target product with IRP(s) as mosquitocidal agent.
Principal Investigator : Dickson Msaki
Department Name :
Time frame: (2022-09-23) - (2022-09-30)
Innovative Vector Control Consortium (IVCC) (Normal)
The Trustees of Indiana University (Prime)
External Collaborating Partners
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